Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
PFAM Sites
| Site | Peptides | |
|---|---|---|
| None | 510 | |
| Pkinase | 14 | |
| Proteasome | 3 | |
| His_Phos_1 | 2 | |
| RRM_1 | 2 | |
| SH2 | 2 | |
| Pkinase_Tyr | 2 | |
| Enolase_N | 2 | |
| PGK | 2 | |
| PWWP | 1 | |
| SUI1 | 1 | |
| PX | 1 | |
| EF-1_beta_acid | 1 | |
| Ras | 1 | |
| WH1 | 1 | |
| FERM_M | 1 | |
| 14-3-3 | 1 | |
| tRNA_SAD | 1 | |
| Rsm1 | 1 | |
| Profilin | 1 | |
| G6PD_C | 1 | |
| HJURP_C | 1 | |
| Filamin | 1 | |
| Aminotran_1_2 | 1 | |
| Gelsolin | 1 | |
| SH3_1 | 1 | |
| Laminin_G_3 | 1 | |
| Myosin_head | 1 | |
| PBP | 1 | |
| Med24_N | 1 | |
| IPP-2 | 1 | |
| APC2 | 1 | |
| RhoGEF | 1 | |
| GTP_EFTU | 1 | |
| PGM_PMM_I | 1 | |
| PB1 | 1 |
PFAM Domains
| Domain | Peptides | |
|---|---|---|
| None | 148 | |
| Pkinase | 21 | |
| RRM_1 | 18 | |
| PH | 12 | |
| SH3_1 | 11 | |
| SH2 | 10 | |
| CH | 7 | |
| SH3_2 | 7 | |
| C2 | 6 | |
| RhoGAP | 6 | |
| Bromodomain | 5 | |
| Pkinase_Tyr | 5 | |
| LIM | 5 | |
| RRM_6 | 4 | |
| DEAD | 4 | |
| SAM_2 | 4 | |
| zf-B_box | 4 | |
| WW | 4 | |
| EF_hand_5 | 4 | |
| PWWP | 3 | |
| Proteasome | 3 | |
| KH_1 | 3 | |
| C1_1 | 3 | |
| GTP_EFTU | 3 | |
| GTP_EFTU_D2 | 3 | |
| zf-RanBP | 3 | |
| zf-RING_2 | 3 | |
| RHD | 3 | |
| HECT | 3 | |
| UBA | 3 | |
| cNMP_binding | 3 | |
| RIIa | 3 | |
| PHD | 3 | |
| Vps5 | 2 | |
| PX | 2 | |
| EF1_GNE | 2 | |
| EF-1_beta_acid | 2 | |
| His_Phos_1 | 2 | |
| Death | 2 | |
| ArfGap | 2 | |
| WH1 | 2 | |
| FERM_M | 2 | |
| Myb_DNA-binding | 2 | |
| DUF3585 | 2 | |
| LTD | 2 | |
| IRS | 2 | |
| Y_phosphatase | 2 | |
| Metallophos | 2 | |
| BAR | 2 | |
| SAM_1 | 2 | |
| PID | 2 | |
| HATPase_c | 2 | |
| PDZ | 2 | |
| Proteasome_A_N | 2 | |
| RA | 2 | |
| RRM_5 | 2 | |
| Sp100 | 2 | |
| RhoGEF | 2 | |
| ZZ | 2 | |
| Myosin_head | 2 | |
| Spectrin | 2 | |
| PGM_PMM_I | 2 | |
| PGM_PMM_III | 2 | |
| PGM_PMM_II | 2 | |
| HLH | 1 | |
| CPSase_L_D2 | 1 | |
| CPSase_L_chain | 1 | |
| Biotin_carb_C | 1 | |
| Biotin_lipoyl | 1 | |
| MutS_V | 1 | |
| MutS_III | 1 | |
| MutS_I | 1 | |
| MutS_II | 1 | |
| SUI1 | 1 | |
| ROKNT | 1 | |
| eIF-1a | 1 | |
| Ras | 1 | |
| Anillin | 1 | |
| VASP_tetra | 1 | |
| FERM_C | 1 | |
| FERM_N | 1 | |
| zf-C3HC4_2 | 1 | |
| SWIRM | 1 | |
| LEM | 1 | |
| Hist_deacetyl | 1 | |
| CS | 1 | |
| DBP10CT | 1 | |
| Apc3 | 1 | |
| HRD | 1 | |
| 14-3-3 | 1 | |
| Brix | 1 | |
| tRNA-synt_2b | 1 | |
| HGTP_anticodon | 1 | |
| tRNA_SAD | 1 | |
| zf-C2H2 | 1 | |
| UQ_con | 1 | |
| SSrecog | 1 | |
| Rtt106 | 1 | |
| HMG_box | 1 | |
| zf-C3HC | 1 | |
| Rsm1 | 1 | |
| OSR1_C | 1 | |
| YTH | 1 | |
| La | 1 | |
| zf-RING_LisH | 1 | |
| Mre11_DNA_bind | 1 | |
| Syntaxin | 1 | |
| IF-2 | 1 | |
| CBFD_NFYB_HMF | 1 | |
| B3_4 | 1 | |
| Exo_endo_phos | 1 | |
| Nup96 | 1 | |
| GTP_EFTU_D3 | 1 | |
| Nipped-B_C | 1 | |
| Ank_5 | 1 | |
| Sec7_N | 1 | |
| DNA_gyraseB | 1 | |
| DSPc | 1 | |
| DEK_C | 1 | |
| CSD | 1 | |
| Profilin | 1 | |
| G6PD_C | 1 | |
| G6PD_N | 1 | |
| Acyl_transf_1 | 1 | |
| ketoacyl-synt | 1 | |
| Ketoacyl-synt_C | 1 | |
| PP-binding | 1 | |
| Methyltransf_12 | 1 | |
| zf-HC5HC2H | 1 | |
| Med26 | 1 | |
| Pribosyltran | 1 | |
| IRF-2BP1_2 | 1 | |
| zf-C3HC4 | 1 | |
| HJURP_mid | 1 | |
| HJURP_C | 1 | |
| Filamin | 1 | |
| CTP_transf_2 | 1 | |
| PK_C | 1 | |
| RRM_3 | 1 | |
| NUC173 | 1 | |
| CDC48_N | 1 | |
| CDC48_2 | 1 | |
| NTF2 | 1 | |
| CHZ | 1 | |
| Aminotran_1_2 | 1 | |
| TIG | 1 | |
| EBP50_C-term | 1 | |
| Pribosyltran_N | 1 | |
| Cyclin_N | 1 | |
| cwf21 | 1 | |
| DUF1900 | 1 | |
| DUF1899 | 1 | |
| Gelsolin | 1 | |
| ABC_tran | 1 | |
| ABC_tran_2 | 1 | |
| ubiquitin | 1 | |
| Aurora-A_bind | 1 | |
| STAT_bind | 1 | |
| STAT_int | 1 | |
| DUF4208 | 1 | |
| Chromo | 1 | |
| CAMSAP_CH | 1 | |
| NUC153 | 1 | |
| Serine_rich | 1 | |
| PP28 | 1 | |
| Laminin_G_3 | 1 | |
| KAT11 | 1 | |
| Creb_binding | 1 | |
| KIX | 1 | |
| DUF902 | 1 | |
| DUF4217 | 1 | |
| GIT1_C | 1 | |
| 53-BP1_Tudor | 1 | |
| Myosin_N | 1 | |
| F_actin_bind | 1 | |
| AAA_33 | 1 | |
| Sushi | 1 | |
| Cbl_N | 1 | |
| Cbl_N3 | 1 | |
| Cbl_N2 | 1 | |
| zf-C3HC4_3 | 1 | |
| Treacle | 1 | |
| muHD | 1 | |
| efhand_Ca_insen | 1 | |
| PBP | 1 | |
| Ribosomal_S3_C | 1 | |
| KH_2 | 1 | |
| YjeF_N | 1 | |
| LSM14 | 1 | |
| Peptidase_C48 | 1 | |
| GYF | 1 | |
| Myb_DNA-bind_2 | 1 | |
| PBD | 1 | |
| DBR1 | 1 | |
| UBX | 1 | |
| Enolase_C | 1 | |
| Enolase_N | 1 | |
| CTD | 1 | |
| Spt5_N | 1 | |
| Anticodon_1 | 1 | |
| GST_N | 1 | |
| GST_C | 1 | |
| Med24_N | 1 | |
| zf-UBP | 1 | |
| DKCLD | 1 | |
| Methyltransf_3 | 1 | |
| IPP-2 | 1 | |
| S10_plectin | 1 | |
| Focal_AT | 1 | |
| APC2 | 1 | |
| Tis11B_N | 1 | |
| zf-CCCH | 1 | |
| FYVE | 1 | |
| Bcr-Abl_Oligo | 1 | |
| PGK | 1 | |
| zf-RNPHF | 1 | |
| GATase_5 | 1 | |
| AIRS | 1 | |
| AIRS_C | 1 | |
| USP8_dimer | 1 | |
| Cir_N | 1 | |
| EFG_IV | 1 | |
| EFG_C | 1 | |
| Pro_isomerase | 1 | |
| IR1-M | 1 | |
| zf-C2H2_6 | 1 | |
| SM-ATX | 1 | |
| LsmAD | 1 | |
| Nup35_RRM | 1 | |
| NOSIC | 1 | |
| NOP5NT | 1 | |
| PB1 | 1 | |
| NUC202 | 1 | |
| RIX1 | 1 | |
| GATase_2 | 1 |