Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
PFAM Sites
| Site | Peptides | |
|---|---|---|
| None | 4386 | |
| Pkinase | 80 | |
| Pkinase_Tyr | 51 | |
| SH2 | 18 | |
| Filamin | 18 | |
| Band_3_cyto | 17 | |
| G6PD_C | 10 | |
| Ras | 9 | |
| Dynein_heavy | 8 | |
| zf-H2C2_2 | 7 | |
| PID | 7 | |
| Sec8_exocyst | 7 | |
| GTP_EFTU | 6 | |
| DUF1908 | 6 | |
| LTD | 5 | |
| Proteasome | 5 | |
| EF_hand_5 | 5 | |
| fn3 | 5 | |
| SH3_1 | 4 | |
| PBD | 4 | |
| Integrin_b_cyt | 4 | |
| Ldh_1_C | 4 | |
| His_Phos_1 | 4 | |
| Enolase_N | 4 | |
| FCP1_C | 4 | |
| Rotamase_3 | 4 | |
| Drf_FH3 | 4 | |
| PGK | 4 | |
| SH3_2 | 3 | |
| LMWPc | 3 | |
| UBX | 3 | |
| Enolase_C | 3 | |
| Med24_N | 3 | |
| PX | 3 | |
| Transketolase_N | 2 | |
| PH | 2 | |
| Methyltransf_3 | 2 | |
| Myosin_head | 2 | |
| SSB | 2 | |
| AAA_33 | 2 | |
| Spectrin | 2 | |
| GST_N | 2 | |
| WH1 | 2 | |
| HATPase_c | 2 | |
| NDK | 2 | |
| GAT | 2 | |
| S10_plectin | 2 | |
| SAM_1 | 2 | |
| G-alpha | 2 | |
| Ala_racemase_N | 2 | |
| Tubulin | 1 | |
| Tubulin_C | 1 | |
| RhoGEF | 1 | |
| Glycolytic | 1 | |
| Flavodoxin_2 | 1 | |
| Citrate_synt | 1 | |
| Ligase_CoA | 1 | |
| Ribosomal_L7Ae | 1 | |
| FERM_N | 1 | |
| Histone | 1 | |
| 3-PAP | 1 | |
| Calx-beta | 1 | |
| STAT_bind | 1 | |
| Cofilin_ADF | 1 | |
| Pyr_redox_dim | 1 | |
| Biotin_carb_C | 1 | |
| zf-C3HC4_2 | 1 | |
| LIM | 1 | |
| PFK | 1 | |
| KH_1 | 1 | |
| FERM_M | 1 | |
| MIF | 1 | |
| LSM | 1 | |
| NOPS | 1 | |
| ArfGap | 1 | |
| zf-RNPHF | 1 | |
| S_100 | 1 | |
| Ribosomal_L11_N | 1 | |
| Hydrolase | 1 | |
| ADK | 1 | |
| BOP1NT | 1 | |
| Y_phosphatase | 1 | |
| IMPDH | 1 | |
| Fork_head | 1 | |
| Biliv-reduc_cat | 1 | |
| Occludin_ELL | 1 | |
| 4_1_CTD | 1 | |
| FERM_C | 1 | |
| CS | 1 | |
| FumaraseC_C | 1 | |
| SOCS_box | 1 | |
| zf-U1 | 1 | |
| PGM_PMM_III | 1 | |
| RRM_1 | 1 |
PFAM Domains
| Domain | Peptides | |
|---|---|---|
| None | 381 | |
| Pkinase | 57 | |
| Pkinase_Tyr | 37 | |
| SH3_1 | 36 | |
| PDZ | 32 | |
| PH | 32 | |
| SH2 | 28 | |
| RhoGAP | 18 | |
| FERM_M | 15 | |
| SH3_2 | 14 | |
| CH | 14 | |
| RhoGEF | 13 | |
| FERM_N | 12 | |
| SAM_1 | 12 | |
| C2 | 12 | |
| RRM_1 | 12 | |
| fn3 | 12 | |
| I-set | 11 | |
| LIM | 10 | |
| zf-H2C2_2 | 9 | |
| FERM_C | 9 | |
| SAM_2 | 9 | |
| C1_1 | 8 | |
| WW | 8 | |
| Kinesin | 7 | |
| Ras | 7 | |
| PID | 7 | |
| RA | 7 | |
| Y_phosphatase | 6 | |
| ArfGap | 6 | |
| PHD | 5 | |
| Ig_2 | 5 | |
| Bromodomain | 5 | |
| PBD | 5 | |
| V-set | 5 | |
| Ank_4 | 5 | |
| Ephrin_lbd | 5 | |
| DEAD | 5 | |
| Myosin_head | 5 | |
| C2-set_2 | 4 | |
| Fork_head | 4 | |
| RBD | 4 | |
| zf-C3HC4_2 | 4 | |
| Death | 4 | |
| Recep_L_domain | 4 | |
| MARVEL | 4 | |
| VHP | 3 | |
| Gelsolin | 3 | |
| WH1 | 3 | |
| VASP_tetra | 3 | |
| HMG_box | 3 | |
| zf-HC5HC2H_2 | 3 | |
| GTPase_binding | 3 | |
| RRM_6 | 3 | |
| Syntaxin | 3 | |
| HECT | 3 | |
| Integrin_B_tail | 3 | |
| GTP_EFTU | 3 | |
| GTP_EFTU_D2 | 3 | |
| Filamin | 3 | |
| zf-B_box | 3 | |
| IRS | 3 | |
| zf-C3HC4_3 | 3 | |
| 4_1_CTD | 3 | |
| SAB | 3 | |
| STAT_bind | 3 | |
| STAT_int | 3 | |
| Cofilin_ADF | 3 | |
| dDENN | 3 | |
| La | 3 | |
| Kunitz_BPTI | 3 | |
| Band_3_cyto | 3 | |
| Sec7 | 3 | |
| UBA | 3 | |
| LSM | 3 | |
| Spectrin | 3 | |
| EF_hand_5 | 3 | |
| DUF3585 | 3 | |
| HATPase_c | 3 | |
| zf-C2H2 | 2 | |
| CAP_GLY | 2 | |
| UBX | 2 | |
| zf-HC5HC2H | 2 | |
| LTD | 2 | |
| efhand | 2 | |
| HATPase_c_3 | 2 | |
| Proteasome | 2 | |
| DnaJ | 2 | |
| Myb_DNA-binding | 2 | |
| F5_F8_type_C | 2 | |
| CUB | 2 | |
| Integrin_b_cyt | 2 | |
| HLH | 2 | |
| EGF_CA | 2 | |
| Serine_rich | 2 | |
| Y_phosphatase_m | 2 | |
| Calx-beta | 2 | |
| Talin_middle | 2 | |
| VBS | 2 | |
| Ldh_1_C | 2 | |
| zf-RING_2 | 2 | |
| PWWP | 2 | |
| KA1 | 2 | |
| His_Phos_1 | 2 | |
| Reprolysin | 2 | |
| Disintegrin | 2 | |
| uDENN | 2 | |
| TIG | 2 | |
| Cyclin_N | 2 | |
| APP_E2 | 2 | |
| APP_N | 2 | |
| APP_Cu_bd | 2 | |
| IMPDH | 2 | |
| KH_1 | 2 | |
| BAR | 2 | |
| AAA_33 | 2 | |
| Sec7_N | 2 | |
| HA2 | 2 | |
| OB_NTP_bind | 2 | |
| Ets | 2 | |
| SAM_PNT | 2 | |
| GAT | 2 | |
| S10_plectin | 2 | |
| Peptidase_C48 | 2 | |
| PDZ_assoc | 2 | |
| MOBP_C-Myrip | 2 | |
| Hist_deacetyl | 2 | |
| HDAC4_Gln | 2 | |
| DUF1908 | 2 | |
| GIT1_C | 2 | |
| V-SNARE_C | 2 | |
| Drf_FH3 | 2 | |
| Drf_GBD | 2 | |
| LSM14 | 2 | |
| PX | 2 | |
| cNMP_binding | 2 | |
| Occludin_ELL | 2 | |
| Cadherin_pro | 2 | |
| Tubulin | 1 | |
| Tubulin_C | 1 | |
| ABC_tran | 1 | |
| Glycolytic | 1 | |
| Flavodoxin_2 | 1 | |
| zf-CXXC | 1 | |
| Focal_AT | 1 | |
| PAP_central | 1 | |
| PAP_RNA-bind | 1 | |
| UCH | 1 | |
| ubiquitin | 1 | |
| zf-CW | 1 | |
| LMWPc | 1 | |
| zf-C2H2_4 | 1 | |
| efhand_like | 1 | |
| Citrate_synt | 1 | |
| Ligase_CoA | 1 | |
| CoA_binding | 1 | |
| Ribosomal_L7Ae | 1 | |
| Transketolase_N | 1 | |
| Transket_pyr | 1 | |
| Transketolase_C | 1 | |
| LCCL | 1 | |
| Laminin_G_2 | 1 | |
| Radical_SAM | 1 | |
| TRAM | 1 | |
| Histone | 1 | |
| Sec8_exocyst | 1 | |
| GTP_EFTU_D3 | 1 | |
| G6PD_C | 1 | |
| G6PD_N | 1 | |
| Myotub-related | 1 | |
| 3-PAP | 1 | |
| ig | 1 | |
| HSA | 1 | |
| GST_N_3 | 1 | |
| zf-C4 | 1 | |
| Hormone_recep | 1 | |
| EpoR_lig-bind | 1 | |
| zf-C3HC | 1 | |
| Rsm1 | 1 | |
| adh_short | 1 | |
| LSR | 1 | |
| TRAM_LAG1_CLN8 | 1 | |
| 6PF2K | 1 | |
| EF_hand_4 | 1 | |
| DUF3481 | 1 | |
| Med1 | 1 | |
| Pro_isomerase | 1 | |
| RNA_pol_A_bac | 1 | |
| RRM_5 | 1 | |
| PET | 1 | |
| Transglut_N | 1 | |
| Transglut_C | 1 | |
| RRM_3 | 1 | |
| Pyr_redox_2 | 1 | |
| Pyr_redox_dim | 1 | |
| CPSase_L_D2 | 1 | |
| CPSase_L_chain | 1 | |
| Biotin_carb_C | 1 | |
| Biotin_lipoyl | 1 | |
| GATase_5 | 1 | |
| AIRS | 1 | |
| AIRS_C | 1 | |
| SRI | 1 | |
| AAA_12 | 1 | |
| AAA_11 | 1 | |
| zf-4CXXC_R1 | 1 | |
| PHR | 1 | |
| Methyltransf_3 | 1 | |
| Med25 | 1 | |
| SNF2_N | 1 | |
| RB_A | 1 | |
| RB_B | 1 | |
| SSB | 1 | |
| RGS | 1 | |
| Nup_retrotrp_bd | 1 | |
| zf-RanBP | 1 | |
| PFK | 1 | |
| Agenet | 1 | |
| Clathrin_H_link | 1 | |
| Clathrin-link | 1 | |
| L27_N | 1 | |
| Rho_Binding | 1 | |
| tRNA_anti | 1 | |
| CARD | 1 | |
| SH3_9 | 1 | |
| TUDOR | 1 | |
| N-SET | 1 | |
| Rhodanese | 1 | |
| CABIT | 1 | |
| SRF-TF | 1 | |
| HJURP_C | 1 | |
| Enolase_C | 1 | |
| Enolase_N | 1 | |
| MIF | 1 | |
| RGS-like | 1 | |
| BAH | 1 | |
| GATA | 1 | |
| NOPS | 1 | |
| Anth_Ig | 1 | |
| VWA | 1 | |
| efhand_Ca_insen | 1 | |
| Profilin | 1 | |
| CSD | 1 | |
| Ank_5 | 1 | |
| GST_C | 1 | |
| GST_N | 1 | |
| zf-RNPHF | 1 | |
| S_100 | 1 | |
| Cystatin | 1 | |
| FCP1_C | 1 | |
| GBP | 1 | |
| GBP_C | 1 | |
| Aldolase_II | 1 | |
| Sushi | 1 | |
| FYRN | 1 | |
| FH2 | 1 | |
| UME | 1 | |
| IF-2 | 1 | |
| Chromo | 1 | |
| Ribosomal_L11_N | 1 | |
| Ribosomal_L11 | 1 | |
| MAGUK_N_PEST | 1 | |
| L27_1 | 1 | |
| UEV | 1 | |
| Vps23_core | 1 | |
| Pentaxin | 1 | |
| MVP_shoulder | 1 | |
| zf-C3H1 | 1 | |
| CUT | 1 | |
| Homeobox | 1 | |
| Ank_2 | 1 | |
| PNP_UDP_1 | 1 | |
| Rotamase_3 | 1 | |
| Hydrolase | 1 | |
| Cation_ATPase_N | 1 | |
| BRCT_assoc | 1 | |
| DNA_gyraseB | 1 | |
| ADK | 1 | |
| RS4NT | 1 | |
| S4 | 1 | |
| Lep_receptor_Ig | 1 | |
| IL6Ra-bind | 1 | |
| Autophagy_N | 1 | |
| Autophagy_act_C | 1 | |
| Autophagy_Cterm | 1 | |
| ZZ | 1 | |
| Med13_N | 1 | |
| NOGCT | 1 | |
| CHZ | 1 | |
| NDK | 1 | |
| DSPc | 1 | |
| DEK_C | 1 | |
| Metallophos | 1 | |
| Cbl_N | 1 | |
| Cbl_N3 | 1 | |
| Cbl_N2 | 1 | |
| YjeF_N | 1 | |
| Alpha_adaptinC2 | 1 | |
| MIT | 1 | |
| CRAL_TRIO_2 | 1 | |
| RFX_DNA_binding | 1 | |
| BOP1NT | 1 | |
| Carb_anhydrase | 1 | |
| FKBP_C | 1 | |
| Kelch_3 | 1 | |
| DED | 1 | |
| PLDc_3 | 1 | |
| Bromo_TP | 1 | |
| Cadherin_2 | 1 | |
| muHD | 1 | |
| Sp100 | 1 | |
| DUF1898 | 1 | |
| Connexin_CCC | 1 | |
| TFR_dimer | 1 | |
| Anillin | 1 | |
| PP28 | 1 | |
| UQ_con | 1 | |
| BIR | 1 | |
| Aminotran_1_2 | 1 | |
| DSL | 1 | |
| EGF | 1 | |
| dsrm | 1 | |
| zf-DBF | 1 | |
| Biliv-reduc_cat | 1 | |
| Med24_N | 1 | |
| c-SKI_SMAD_bind | 1 | |
| KAP_NTPase | 1 | |
| DEP | 1 | |
| FYVE | 1 | |
| GATase_2 | 1 | |
| PGK | 1 | |
| DUF3651 | 1 | |
| PI3K_C2 | 1 | |
| SMC_hinge | 1 | |
| CRIC_ras_sig | 1 | |
| EBP50_C-term | 1 | |
| Myosin_N | 1 | |
| Dynein_heavy | 1 | |
| AAA_8 | 1 | |
| AAA_9 | 1 | |
| MT | 1 | |
| DUF4151 | 1 | |
| AAA_5 | 1 | |
| TLD | 1 | |
| LysM | 1 | |
| MH1 | 1 | |
| Rapamycin_bind | 1 | |
| MBD | 1 | |
| MANEC | 1 | |
| CS | 1 | |
| IL1 | 1 | |
| zf-C2H2_6 | 1 | |
| Hrs_helical | 1 | |
| Med26 | 1 | |
| Lyase_1 | 1 | |
| FumaraseC_C | 1 | |
| cwf21 | 1 | |
| OSR1_C | 1 | |
| Bcr-Abl_Oligo | 1 | |
| Ig_3 | 1 | |
| SOCS_box | 1 | |
| MIB_HERC2 | 1 | |
| G-alpha | 1 | |
| Guanylate_cyc | 1 | |
| Proteasome_A_N | 1 | |
| zf-U1 | 1 | |
| PGM_PMM_I | 1 | |
| PGM_PMM_III | 1 | |
| PGM_PMM_II | 1 | |
| IRF-2BP1_2 | 1 | |
| Exo_endo_phos | 1 | |
| F-box-like | 1 | |
| Ala_racemase_N | 1 | |
| STAS | 1 | |
| Sulfate_tra_GLY | 1 | |
| Nipped-B_C | 1 | |
| FDF | 1 |