Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules
Scansite Bind
| Domain | Peptides | |
|---|---|---|
| None | 64 | |
| Abl_SH2 | 8 | |
| Crk_SH2 | 6 | |
| Shc_PTB | 4 | |
| Lck_SH2 | 4 | |
| Itk_SH2 | 4 | |
| Nck_SH2 | 4 | |
| Grb2_SH2 | 3 | |
| SHIP_SH2 | 3 | |
| Fgr_SH2 | 2 | |
| Fyn_SH2 | 2 | |
| 1433_m1 | 1 | |
| AuroA | 1 | |
| AuroB | 1 | |
| Src_SH2 | 1 | |
| p85_SH2 | 1 |
Scansite Kinase
| Domain | Peptides | |
|---|---|---|
| None | 66 | |
| Abl_Kin | 10 | |
| EGFR_Kin | 6 | |
| Src_Kin | 4 | |
| Lck_Kin | 4 | |
| Fgr_Kin | 3 | |
| PDGFR_Kin | 2 | |
| Itk_Kin | 2 | |
| Akt_Kin | 1 | |
| PKA_Kin | 1 | |
| InsR_Kin | 1 |