Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

GO Map

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Molecular Functions

GO Term Proteins
temp GO:0005515 protein binding 33
temp None - 31
temp GO:0098641 cadherin binding involved in cell-cell adhesion 11
temp GO:0005102 receptor binding 6
temp GO:0042802 identical protein binding 6
temp GO:0019903 protein phosphatase binding 5
temp GO:0004713 protein tyrosine kinase activity 4
temp GO:0019901 protein kinase binding 4
temp GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 4
temp GO:0004672 protein kinase activity 3
temp GO:0004714 transmembrane receptor protein tyrosine kinase activity 3
temp GO:0004715 non-membrane spanning protein tyrosine kinase activity 3
temp GO:0005070 SH3/SH2 adaptor activity 3
temp GO:0005088 Ras guanyl-nucleotide exchange factor activity 3
temp GO:0030971 receptor tyrosine kinase binding 3
temp GO:0046982 protein heterodimerization activity 3
temp GO:0003700 sequence-specific DNA binding transcription factor activity 2
temp GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2
temp GO:0004888 transmembrane signaling receptor activity 2
temp GO:0005006 epidermal growth factor-activated receptor activity 2
temp GO:0005198 structural molecule activity 2
temp GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2
temp GO:0016303 1-phosphatidylinositol-3-kinase activity 2
temp GO:0019899 enzyme binding 2
temp GO:0031625 ubiquitin protein ligase binding 2
temp GO:0042169 SH2 domain binding 2
temp GO:0044822 poly(A) RNA binding 2
temp GO:0045294 alpha-catenin binding 2
temp GO:0045296 cadherin binding 2
temp GO:0046983 protein dimerization activity 2
temp GO:0050839 cell adhesion molecule binding 2
temp GO:0051015 actin filament binding 2
temp GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication 2
temp GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 1
temp GO:0001042 RNA polymerase I core binding 1
temp GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 1
temp GO:0001103 RNA polymerase II repressing transcription factor binding 1
temp GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 1
temp GO:0002020 protease binding 1
temp GO:0003677 DNA binding 1
temp GO:0003682 chromatin binding 1
temp GO:0003690 double-stranded DNA binding 1
temp GO:0003713 transcription coactivator activity 1
temp GO:0003779 actin binding 1
temp GO:0003993 acid phosphatase activity 1
temp GO:0004013 adenosylhomocysteinase activity 1
temp GO:0004674 protein serine/threonine kinase activity 1
temp GO:0004693 cyclin-dependent protein kinase activity 1
temp GO:0004709 MAP kinase kinase kinase activity 1
temp GO:0004716 receptor signaling protein tyrosine kinase activity 1
temp GO:0004721 phosphoprotein phosphatase activity 1
temp GO:0004725 protein tyrosine phosphatase activity 1
temp GO:0004842 ubiquitin-protein ligase activity 1
temp GO:0004859 phospholipase inhibitor activity 1
temp GO:0004860 protein kinase inhibitor activity 1
temp GO:0004871 signal transducer activity 1
temp GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity 1
temp GO:0004930 G-protein coupled receptor activity 1
temp GO:0005003 ephrin receptor activity 1
temp GO:0005005 transmembrane-ephrin receptor activity 1
temp GO:0005086 ARF guanyl-nucleotide exchange factor activity 1
temp GO:0005096 GTPase activator activity 1
temp GO:0005113 patched binding 1
temp GO:0005158 insulin receptor binding 1
temp GO:0005199 structural constituent of cell wall 1
temp GO:0005522 profilin binding 1
temp GO:0005544 calcium-dependent phospholipid binding 1
temp GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1
temp GO:0008022 protein C-terminus binding 1
temp GO:0008093 cytoskeletal adaptor activity 1
temp GO:0008134 transcription factor binding 1
temp GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity 1
temp GO:0008432 JUN kinase binding 1
temp GO:0015171 amino acid transmembrane transporter activity 1
temp GO:0015485 cholesterol binding 1
temp GO:0016504 peptidase activator activity 1
temp GO:0017124 SH3 domain binding 1
temp GO:0019834 phospholipase A2 inhibitor activity 1
temp GO:0019838 growth factor binding 1
temp GO:0030159 receptor signaling complex scaffold activity 1
temp GO:0030235 nitric-oxide synthase regulator activity 1
temp GO:0030296 protein tyrosine kinase activator activity 1
temp GO:0030332 cyclin binding 1
temp GO:0030546 receptor activator activity 1
temp GO:0030674 protein binding, bridging 1
temp GO:0031490 chromatin DNA binding 1
temp GO:0031593 polyubiquitin binding 1
temp GO:0032266 phosphatidylinositol-3-phosphate binding 1
temp GO:0032947 protein complex scaffold 1
temp GO:0035173 histone kinase activity 1
temp GO:0035257 nuclear hormone receptor binding 1
temp GO:0042803 protein homodimerization activity 1
temp GO:0043125 ErbB-3 class receptor binding 1
temp GO:0043130 ubiquitin binding 1
temp GO:0044212 transcription regulatory region DNA binding 1
temp GO:0044325 ion channel binding 1
temp GO:0044548 S100 protein binding 1
temp GO:0046875 ephrin receptor binding 1
temp GO:0046935 1-phosphatidylinositol-3-kinase regulator activity 1
temp GO:0048306 calcium-dependent protein binding 1
temp GO:0048365 Rac GTPase binding 1
temp GO:0050998 nitric-oxide synthase binding 1
temp GO:0051117 ATPase binding 1
temp GO:0070320 inward rectifier potassium channel inhibitor activity 1
temp GO:0071074 eukaryotic initiation factor eIF2 binding 1
temp GO:0097472 cyclin-dependent protein kinase activity 1

Cellular Components

GO Term Proteins
None - 33
GO:0005829 cytosol 23
GO:0005886 plasma membrane 22
GO:0005737 cytoplasm 21
GO:0005634 nucleus 14
GO:0070062 extracellular vesicular exosome 12
GO:0005913 cell-cell adherens junction 11
GO:0005925 focal adhesion 9
GO:0016020 membrane 7
GO:0005887 integral to plasma membrane 6
GO:0005654 nucleoplasm 5
GO:0005911 cell-cell junction 5
GO:0016323 basolateral plasma membrane 5
GO:0005615 extracellular space 3
GO:0005622 intracellular 3
GO:0005730 nucleolus 3
GO:0005768 endosome 3
GO:0005783 endoplasmic reticulum 3
GO:0005856 cytoskeleton 3
GO:0009986 cell surface 3
GO:0030496 midbody 3
GO:0031012 extracellular matrix 3
GO:0031234 extrinsic to internal side of plasma membrane 3
GO:0031901 early endosome membrane 3
GO:0031982 vesicle 3
GO:0043231 intracellular membrane-bounded organelle 3
GO:0045121 membrane raft 3
GO:0001726 ruffle 2
GO:0005576 extracellular region 2
GO:0005789 endoplasmic reticulum membrane 2
GO:0005794 Golgi apparatus 2
GO:0005811 lipid particle 2
GO:0005905 coated pit 2
GO:0009898 internal side of plasma membrane 2
GO:0010008 endosome membrane 2
GO:0014704 intercalated disc 2
GO:0016324 apical plasma membrane 2
GO:0030027 lamellipodium 2
GO:0030054 cell junction 2
GO:0030057 desmosome 2
GO:0031410 cytoplasmic vesicle 2
GO:0043235 receptor complex 2
GO:0000139 Golgi membrane 1
GO:0000164 protein phosphatase type 1 complex 1
GO:0000307 cyclin-dependent protein kinase holoenzyme complex 1
GO:0000784 nuclear chromosome, telomeric region 1
GO:0000790 nuclear chromatin 1
GO:0001725 stress fiber 1
GO:0005667 transcription factor complex 1
GO:0005739 mitochondrion 1
GO:0005765 lysosomal membrane 1
GO:0005802 trans-Golgi network 1
GO:0005813 centrosome 1
GO:0005840 ribosome 1
GO:0005876 spindle microtubule 1
GO:0005884 actin filament 1
GO:0005901 caveola 1
GO:0005915 zonula adherens 1
GO:0005916 fascia adherens 1
GO:0005923 tight junction 1
GO:0005938 cell cortex 1
GO:0005942 phosphatidylinositol 3-kinase complex 1
GO:0008076 voltage-gated potassium channel complex 1
GO:0015629 actin cytoskeleton 1
GO:0016021 integral to membrane 1
GO:0016235 aggresome 1
GO:0016342 catenin complex 1
GO:0016604 nuclear body 1
GO:0030018 Z disc 1
GO:0030056 hemidesmosome 1
GO:0030122 AP-2 adaptor complex 1
GO:0030426 growth cone 1
GO:0030666 endocytic vesicle membrane 1
GO:0030863 cortical cytoskeleton 1
GO:0031256 leading edge membrane 1
GO:0031902 late endosome membrane 1
GO:0032993 protein-DNA complex 1
GO:0033269 internode region of axon 1
GO:0033565 ESCRT-0 complex 1
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex 1
GO:0043234 protein complex 1
GO:0044432 endoplasmic reticulum part 1
GO:0048471 perinuclear region of cytoplasm 1
GO:0070435 Shc-EGFR complex 1
GO:0071665 gamma-catenin-TCF7L2 complex 1
GO:0071797 LUBAC complex 1
GO:0072686 mitotic spindle 1
GO:0090575 RNA polymerase II transcription factor complex 1
GO:0097489 multivesicular body, internal vesicle lumen 1
GO:1990667 PCSK9-AnxA2 complex 1

Biological Processes

GO Term Proteins
None - 34
GO:0007411 axon guidance 11
GO:0045087 innate immune response 11
GO:0007173 epidermal growth factor receptor signaling pathway 8
GO:0048010 vascular endothelial growth factor receptor signaling pathway 8
GO:0016477 cell migration 7
GO:0048013 ephrin receptor signaling pathway 7
GO:0046777 protein autophosphorylation 6
GO:0048011 nerve growth factor receptor signaling pathway 6
GO:0007165 signal transduction 5
GO:0007264 small GTPase mediated signal transduction 5
GO:0007596 blood coagulation 5
GO:0008543 fibroblast growth factor receptor signaling pathway 5
GO:0038095 Fc-epsilon receptor signaling pathway 5
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 5
GO:0043066 negative regulation of apoptotic process 5
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 5
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 4
GO:0000165 MAPK cascade 4
GO:0001525 angiogenesis 4
GO:0007155 cell adhesion 4
GO:0014066 regulation of phosphatidylinositol 3-kinase cascade 4
GO:0018108 peptidyl-tyrosine phosphorylation 4
GO:0038083 peptidyl-tyrosine autophosphorylation 4
GO:0042127 regulation of cell proliferation 4
GO:0048015 phosphatidylinositol-mediated signaling 4
GO:0001934 positive regulation of protein phosphorylation 3
GO:0006468 protein phosphorylation 3
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 3
GO:0007399 nervous system development 3
GO:0008283 cell proliferation 3
GO:0008284 positive regulation of cell proliferation 3
GO:0008286 insulin receptor signaling pathway 3
GO:0030036 actin cytoskeleton organization 3
GO:0030168 platelet activation 3
GO:0033628 regulation of cell adhesion mediated by integrin 3
GO:0034329 cell junction assembly 3
GO:0038128 ERBB2 signaling pathway 3
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 3
GO:0045216 cell-cell junction organization 3
GO:0048870 cell motility 3
GO:0050852 T cell receptor signaling pathway 3
GO:0050900 leukocyte migration 3
GO:0060326 cell chemotaxis 3
GO:0070372 regulation of ERK1 and ERK2 cascade 3
GO:0086091 regulation of heart rate by cardiac conduction 3
GO:0098911 regulation of ventricular cardiac muscle cell action potential 3
GO:0000186 activation of MAPKK activity 2
GO:0002159 desmosome assembly 2
GO:0006915 apoptotic process 2
GO:0007010 cytoskeleton organization 2
GO:0007166 cell surface receptor signaling pathway 2
GO:0007179 transforming growth factor beta receptor signaling pathway 2
GO:0007346 regulation of mitotic cell cycle 2
GO:0007507 heart development 2
GO:0010628 positive regulation of gene expression 2
GO:0014065 phosphatidylinositol 3-kinase cascade 2
GO:0016050 vesicle organization 2
GO:0016337 cell-cell adhesion 2
GO:0019065 receptor-mediated endocytosis of virus by host cell 2
GO:0019221 cytokine-mediated signaling pathway 2
GO:0030010 establishment of cell polarity 2
GO:0030154 cell differentiation 2
GO:0030307 positive regulation of cell growth 2
GO:0030335 positive regulation of cell migration 2
GO:0030838 positive regulation of actin filament polymerization 2
GO:0030879 mammary gland development 2
GO:0031295 T cell costimulation 2
GO:0033137 negative regulation of peptidyl-serine phosphorylation 2
GO:0034332 adherens junction organization 2
GO:0035335 peptidyl-tyrosine dephosphorylation 2
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein 2
GO:0043087 regulation of GTPase activity 2
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 2
GO:0043406 positive regulation of MAP kinase activity 2
GO:0044281 small molecule metabolic process 2
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 2
GO:0045765 regulation of angiogenesis 2
GO:0045893 positive regulation of transcription, DNA-dependent 2
GO:0050679 positive regulation of epithelial cell proliferation 2
GO:0050999 regulation of nitric-oxide synthase activity 2
GO:0051592 response to calcium ion 2
GO:0051897 positive regulation of protein kinase B signaling cascade 2
GO:0051965 positive regulation of synapse assembly 2
GO:0060396 growth hormone receptor signaling pathway 2
GO:0060996 dendritic spine development 2
GO:0060997 dendritic spine morphogenesis 2
GO:0061099 negative regulation of protein tyrosine kinase activity 2
GO:0071364 cellular response to epidermal growth factor stimulus 2
GO:0086005 regulation of ventricular cardiac muscle cell action potential 2
GO:0086069 bundle of His cell to Purkinje myocyte communication 2
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication 2
GO:0090002 establishment of protein localization to plasma membrane 2
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway 2
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway 2
GO:2000145 regulation of cell motility 2
GO:2000811 negative regulation of anoikis 2
GO:2001275 positive regulation of glucose import in response to insulin stimulus 2
GO:0000075 cell cycle checkpoint 1
GO:0000082 G1/S transition of mitotic cell cycle 1
GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle 1
GO:0000086 G2/M transition of mitotic cell cycle 1
GO:0000187 activation of MAPK activity 1
GO:0000188 inactivation of MAPK activity 1
GO:0000209 protein polyubiquitination 1
GO:0000226 microtubule cytoskeleton organization 1
GO:0000278 mitotic cell cycle 1
GO:0000902 cell morphogenesis 1
GO:0001501 skeletal system development 1
GO:0001503 ossification 1
GO:0001570 vasculogenesis 1
GO:0001649 osteoblast differentiation 1
GO:0001655 urogenital system development 1
GO:0001659 temperature homeostasis 1
GO:0001666 response to hypoxia 1
GO:0001678 cellular glucose homeostasis 1
GO:0001754 eye photoreceptor cell differentiation 1
GO:0001765 membrane raft assembly 1
GO:0001890 placenta development 1
GO:0001921 positive regulation of receptor recycling 1
GO:0001932 regulation of protein phosphorylation 1
GO:0001937 negative regulation of endothelial cell proliferation 1
GO:0002042 cell migration involved in sprouting angiogenesis 1
GO:0002091 negative regulation of receptor internalization 1
GO:0002224 toll-like receptor signaling pathway 1
GO:0002576 platelet degranulation 1
GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1
GO:0002756 MyD88-independent toll-like receptor signaling pathway 1
GO:0003007 heart morphogenesis 1
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway 1
GO:0003181 atrioventricular valve morphogenesis 1
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development 1
GO:0003333 amino acid transmembrane transport 1
GO:0006260 DNA replication 1
GO:0006281 DNA repair 1
GO:0006355 regulation of transcription, DNA-dependent 1
GO:0006357 regulation of transcription from RNA polymerase II promoter 1
GO:0006378 mRNA polyadenylation 1
GO:0006461 protein complex assembly 1
GO:0006469 negative regulation of protein kinase activity 1
GO:0006470 protein dephosphorylation 1
GO:0006606 protein import into nucleus 1
GO:0006612 protein targeting to membrane 1
GO:0006641 triglyceride metabolic process 1
GO:0006644 phospholipid metabolic process 1
GO:0006661 phosphatidylinositol biosynthetic process 1
GO:0006811 ion transport 1
GO:0006816 calcium ion transport 1
GO:0006865 amino acid transport 1
GO:0006874 cellular calcium ion homeostasis 1
GO:0006886 intracellular protein transport 1
GO:0006895 Golgi to endosome transport 1
GO:0006898 receptor-mediated endocytosis 1
GO:0006900 membrane budding 1
GO:0006914 autophagy 1
GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1
GO:0006928 cellular component movement 1
GO:0006940 regulation of smooth muscle contraction 1
GO:0006950 response to stress 1
GO:0006954 inflammatory response 1
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1
GO:0006996 organelle organization 1
GO:0007016 cytoskeletal anchoring at plasma membrane 1
GO:0007077 mitotic nuclear envelope disassembly 1
GO:0007098 centrosome cycle 1
GO:0007163 establishment or maintenance of cell polarity 1
GO:0007167 enzyme linked receptor protein signaling pathway 1
GO:0007172 signal complex assembly 1
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 1
GO:0007202 activation of phospholipase C activity 1
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway 1
GO:0007229 integrin-mediated signaling pathway 1
GO:0007249 I-kappaB kinase/NF-kappaB cascade 1
GO:0007259 JAK-STAT cascade 1
GO:0007265 Ras protein signal transduction 1
GO:0007266 Rho protein signal transduction 1
GO:0007267 cell-cell signaling 1
GO:0007268 synaptic transmission 1
GO:0007269 neurotransmitter secretion 1
GO:0007275 multicellular organismal development 1
GO:0007344 pronuclear fusion 1
GO:0007369 gastrulation 1
GO:0007398 ectoderm development 1
GO:0007409 axonogenesis 1
GO:0007413 axonal fasciculation 1
GO:0007420 brain development 1
GO:0007519 skeletal muscle tissue development 1
GO:0007605 sensory perception of sound 1
GO:0007611 learning or memory 1
GO:0008063 Toll signaling pathway 1
GO:0008104 protein localization 1
GO:0008285 negative regulation of cell proliferation 1
GO:0008356 asymmetric cell division 1
GO:0008360 regulation of cell shape 1
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage response 1
GO:0009267 cellular response to starvation 1
GO:0009615 response to virus 1
GO:0009617 response to bacterium 1
GO:0009653 anatomical structure morphogenesis 1
GO:0009790 embryo development 1
GO:0009967 positive regulation of signal transduction 1
GO:0009968 negative regulation of signal transduction 1
GO:0010468 regulation of gene expression 1
GO:0010506 regulation of autophagy 1
GO:0010524 positive regulation of calcium ion transport into cytosol 1
GO:0010591 regulation of lamellipodium assembly 1
GO:0010594 regulation of endothelial cell migration 1
GO:0010632 regulation of epithelial cell migration 1
GO:0010765 positive regulation of sodium ion transport 1
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1
GO:0010976 positive regulation of neuron projection development 1
GO:0012501 programmed cell death 1
GO:0014038 regulation of Schwann cell differentiation 1
GO:0014047 glutamate secretion 1
GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade 1
GO:0016044 cellular membrane organization 1
GO:0016192 vesicle-mediated transport 1
GO:0016197 endosomal transport 1
GO:0016310 phosphorylation 1
GO:0016331 morphogenesis of embryonic epithelium 1
GO:0018105 peptidyl-serine phosphorylation 1
GO:0018107 peptidyl-threonine phosphorylation 1
GO:0019217 regulation of fatty acid metabolic process 1
GO:0019915 lipid storage 1
GO:0019953 sexual reproduction 1
GO:0021952 central nervous system projection neuron axonogenesis 1
GO:0022008 neurogenesis 1
GO:0022011 myelination in peripheral nervous system 1
GO:0022038 corpus callosum development 1
GO:0022407 regulation of cell-cell adhesion 1
GO:0022408 negative regulation of cell-cell adhesion 1
GO:0022604 regulation of cell morphogenesis 1
GO:0023014 signal transduction by phosphorylation 1
GO:0030042 actin filament depolymerization 1
GO:0030193 regulation of blood coagulation 1
GO:0030216 keratinocyte differentiation 1
GO:0030301 cholesterol transport 1
GO:0030316 osteoclast differentiation 1
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 1
GO:0030514 negative regulation of BMP signaling pathway 1
GO:0030516 regulation of axon extension 1
GO:0030522 intracellular receptor mediated signaling pathway 1
GO:0030855 epithelial cell differentiation 1
GO:0030857 negative regulation of epithelial cell differentiation 1
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 1
GO:0031290 retinal ganglion cell axon guidance 1
GO:0031340 positive regulation of vesicle fusion 1
GO:0031397 negative regulation of protein ubiquitination 1
GO:0031398 positive regulation of protein ubiquitination 1
GO:0031440 regulation of mRNA 3'-end processing 1
GO:0031532 actin cytoskeleton reorganization 1
GO:0031589 cell-substrate adhesion 1
GO:0031623 receptor internalization 1
GO:0031643 positive regulation of myelination 1
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S 1
GO:0032088 negative regulation of NF-kappaB transcription factor activity 1
GO:0032091 negative regulation of protein binding 1
GO:0032092 positive regulation of protein binding 1
GO:0032314 regulation of Rac GTPase activity 1
GO:0032319 regulation of Rho GTPase activity 1
GO:0032321 positive regulation of Rho GTPase activity 1
GO:0032355 response to estradiol stimulus 1
GO:0032412 regulation of ion transmembrane transporter activity 1
GO:0032456 endocytic recycling 1
GO:0032507 maintenance of protein location in cell 1
GO:0032570 response to progesterone stimulus 1
GO:0032675 regulation of interleukin-6 production 1
GO:0032757 positive regulation of interleukin-8 production 1
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process 1
GO:0032863 activation of Rac GTPase activity 1
GO:0032869 cellular response to insulin stimulus 1
GO:0032870 cellular response to hormone stimulus 1
GO:0032886 regulation of microtubule-based process 1
GO:0033138 positive regulation of peptidyl-serine phosphorylation 1
GO:0033210 leptin-mediated signaling pathway 1
GO:0033353 S-adenosylmethionine cycle 1
GO:0033484 nitric oxide homeostasis 1
GO:0033598 mammary gland epithelial cell proliferation 1
GO:0034130 toll-like receptor 1 signaling pathway 1
GO:0034134 toll-like receptor 2 signaling pathway 1
GO:0034138 toll-like receptor 3 signaling pathway 1
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway 1
GO:0034142 toll-like receptor 4 signaling pathway 1
GO:0034146 toll-like receptor 5 signaling pathway 1
GO:0034162 toll-like receptor 9 signaling pathway 1
GO:0034166 toll-like receptor 10 signaling pathway 1
GO:0034446 substrate adhesion-dependent cell spreading 1
GO:0034501 protein localization to kinetochore 1
GO:0034976 response to endoplasmic reticulum stress 1
GO:0035019 somatic stem cell maintenance 1
GO:0035278 negative regulation of translation involved in gene silencing by miRNA 1
GO:0035413 positive regulation of catenin import into nucleus 1
GO:0035666 TRIF-dependent toll-like receptor signaling pathway 1
GO:0036035 osteoclast development 1
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1
GO:0036258 multivesicular body assembly 1
GO:0036302 atrioventricular canal development 1
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress 1
GO:0038007 netrin-activated signaling pathway 1
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway 1
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway 1
GO:0038127 ERBB signaling pathway 1
GO:0038166 angiotensin-mediated signaling pathway 1
GO:0042060 wound healing 1
GO:0042102 positive regulation of T cell proliferation 1
GO:0042110 T cell activation 1
GO:0042177 negative regulation of protein catabolic process 1
GO:0042307 positive regulation of protein import into nucleus 1
GO:0042327 positive regulation of phosphorylation 1
GO:0042503 tyrosine phosphorylation of Stat3 protein 1
GO:0042506 tyrosine phosphorylation of Stat5 protein 1
GO:0042593 glucose homeostasis 1
GO:0042632 cholesterol homeostasis 1
GO:0042659 regulation of cell fate specification 1
GO:0042755 eating behavior 1
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1
GO:0042981 regulation of apoptotic process 1
GO:0042993 positive regulation of transcription factor import into nucleus 1
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling 1
GO:0043085 positive regulation of catalytic activity 1
GO:0043086 negative regulation of catalytic activity 1
GO:0043088 regulation of Cdc42 GTPase activity 1
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade 1
GO:0043254 regulation of protein complex assembly 1
GO:0043409 negative regulation of MAPK cascade 1
GO:0043491 protein kinase B signaling cascade 1
GO:0043535 regulation of blood vessel endothelial cell migration 1
GO:0043547 positive regulation of GTPase activity 1
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 1
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1
GO:0043588 skin development 1
GO:0043627 response to estrogen stimulus 1
GO:0044320 cellular response to leptin stimulus 1
GO:0044321 response to leptin stimulus 1
GO:0044772 mitotic cell cycle phase transition 1
GO:0044794 positive regulation by host of viral process 1
GO:0044860 protein localization to plasma membrane raft 1
GO:0045019 negative regulation of nitric oxide biosynthetic process 1
GO:0045429 positive regulation of nitric oxide biosynthetic process 1
GO:0045667 regulation of osteoblast differentiation 1
GO:0045727 positive regulation of translation 1
GO:0045739 positive regulation of DNA repair 1
GO:0045740 positive regulation of DNA replication 1
GO:0045747 positive regulation of Notch signaling pathway 1
GO:0045785 positive regulation of cell adhesion 1
GO:0045787 positive regulation of cell cycle 1
GO:0045860 positive regulation of protein kinase activity 1
GO:0045907 positive regulation of vasoconstriction 1
GO:0045943 positive regulation of transcription from RNA polymerase I promoter 1
GO:0045945 positive regulation of transcription from RNA polymerase III promoter 1
GO:0045987 positive regulation of smooth muscle contraction 1
GO:0045995 regulation of embryonic development 1
GO:0046058 cAMP metabolic process 1
GO:0046209 nitric oxide metabolic process 1
GO:0046328 regulation of JNK cascade 1
GO:0046426 negative regulation of JAK-STAT cascade 1
GO:0046718 viral entry into host cell 1
GO:0046849 bone remodeling 1
GO:0046854 phosphatidylinositol phosphorylation 1
GO:0048041 focal adhesion assembly 1
GO:0048268 clathrin coat assembly 1
GO:0048514 blood vessel morphogenesis 1
GO:0048538 thymus development 1
GO:0048546 digestive tract morphogenesis 1
GO:0048550 negative regulation of pinocytosis 1
GO:0048554 positive regulation of metalloenzyme activity 1
GO:0048599 oocyte development 1
GO:0048706 embryonic skeletal system development 1
GO:0048708 astrocyte differentiation 1
GO:0048806 genitalia development 1
GO:0048812 neuron projection morphogenesis 1
GO:0048839 inner ear development 1
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 1
GO:0050770 regulation of axonogenesis 1
GO:0050920 regulation of chemotaxis 1
GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1
GO:0050982 detection of mechanical stimulus 1
GO:0051056 regulation of small GTPase mediated signal transduction 1
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity 1
GO:0051092 positive regulation of NF-kappaB transcription factor activity 1
GO:0051205 protein insertion into membrane 1
GO:0051260 protein homooligomerization 1
GO:0051290 protein heterotetramerization 1
GO:0051403 stress-activated MAPK cascade 1
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1
GO:0051445 regulation of meiotic cell cycle 1
GO:0051480 cytosolic calcium ion homeostasis 1
GO:0051493 regulation of cytoskeleton organization 1
GO:0051726 regulation of cell cycle 1
GO:0051893 regulation of focal adhesion assembly 1
GO:0051898 negative regulation of protein kinase B signaling cascade 1
GO:0051899 membrane depolarization 1
GO:0052547 regulation of peptidase activity 1
GO:0055074 calcium ion homeostasis 1
GO:0055085 transmembrane transport 1
GO:0060019 radial glial cell differentiation 1
GO:0060021 palate development 1
GO:0060056 mammary gland involution 1
GO:0060259 regulation of feeding behavior 1
GO:0060325 face morphogenesis 1
GO:0060333 interferon-gamma-mediated signaling pathway 1
GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1
GO:0060337 type I interferon-mediated signaling pathway 1
GO:0060338 regulation of type I interferon-mediated signaling pathway 1
GO:0060355 positive regulation of cell adhesion molecule production 1
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway 1
GO:0060444 branching involved in mammary gland duct morphogenesis 1
GO:0060548 negative regulation of cell death 1
GO:0060575 intestinal epithelial cell differentiation 1
GO:0061001 regulation of dendritic spine morphogenesis 1
GO:0061024 membrane organization 1
GO:0061098 positive regulation of protein tyrosine kinase activity 1
GO:0061351 neural precursor cell proliferation 1
GO:0070102 interleukin-6-mediated signaling pathway 1
GO:0070141 response to UV-A 1
GO:0070262 peptidyl-serine dephosphorylation 1
GO:0070309 lens fiber cell morphogenesis 1
GO:0070374 positive regulation of ERK1 and ERK2 cascade 1
GO:0070830 tight junction assembly 1
GO:0070836 caveola assembly 1
GO:0070848 response to growth factor stimulus 1
GO:0071300 cellular response to retinoic acid 1
GO:0071360 cellular response to exogenous dsRNA 1
GO:0071363 cellular response to growth factor stimulus 1
GO:0071375 cellular response to peptide hormone stimulus 1
GO:0071392 cellular response to estradiol stimulus 1
GO:0071455 cellular response to hyperoxia 1
GO:0071603 endothelial cell-cell adhesion 1
GO:0071681 cellular response to indole-3-methanol 1
GO:0072584 caveolin-mediated endocytosis 1
GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion 1
GO:0086098 angiotensin-activated signaling pathway involved in heart process 1
GO:0090004 positive regulation of establishment of protein localization to plasma membrane 1
GO:0090162 establishment of epithelial cell polarity 1
GO:0090166 Golgi disassembly 1
GO:0090314 positive regulation of protein targeting to membrane 1
GO:0090630 activation of GTPase activity 1
GO:0097009 energy homeostasis 1
GO:0097039 protein linear polyubiquitination 1
GO:0097190 apoptotic signaling pathway 1
GO:0097581 lamellipodium organization 1
GO:0098903 regulation of membrane repolarization during action potential 1
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction 1
GO:1900020 positive regulation of protein kinase C activity 1
GO:1900024 regulation of substrate adhesion-dependent cell spreading 1
GO:1900027 regulation of ruffle assembly 1
GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation 1
GO:1900121 negative regulation of receptor binding 1
GO:1900182 positive regulation of protein localization to nucleus 1
GO:1901214 regulation of neuron death 1
GO:1901380 negative regulation of potassium ion transmembrane transport 1
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1
GO:1901979 regulation of inward rectifier potassium channel activity 1
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter 1
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 1
GO:1903078 positive regulation of protein localization to plasma membrane 1
GO:1903361 protein localization to basolateral plasma membrane 1
GO:1903543 positive regulation of exosomal secretion 1
GO:1903551 regulation of extracellular vesicular exosome assembly 1
GO:1903598 positive regulation of gap junction assembly 1
GO:1903676 positive regulation of cap-dependent translational initiation 1
GO:1903679 positive regulation of cap-independent translational initiation 1
GO:1903779 regulation of cardiac conduction 1
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1
GO:1903898 negative regulation of PERK-mediated unfolded protein response 1
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 1
GO:1904030 negative regulation of cyclin-dependent protein kinase activity 1
GO:1904685 positive regulation of metalloendopeptidase activity 1
GO:1904886 beta-catenin destruction complex disassembly 1
GO:1905208 negative regulation of cardiocyte differentiation 1
GO:1905581 positive regulation of low-density lipoprotein particle clearance 1
GO:1905597 positive regulation of low-density lipoprotein particle receptor binding 1
GO:1905599 positive regulation of low-density lipoprotein receptor activity 1
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport 1
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1
GO:2000273 positive regulation of receptor activity 1
GO:2000286 receptor internalization involved in canonical Wnt receptor signaling pathway 1
GO:2000535 regulation of entry of bacterium into host cell 1
GO:2000637 positive regulation of gene silencing by miRNA 1
GO:2000727 positive regulation of cardiac muscle cell differentiation 1
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 1
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 1