MEK-Dependent Negative Feedback Underlies BCR-ABL-Mediated Oncogene Addiction
PFAM Sites
| Site | Peptides | |
|---|---|---|
| None | 112 | |
| Pkinase | 13 | |
| Pkinase_Tyr | 10 | |
| Proteasome | 6 | |
| SH2 | 5 | |
| SH3_1 | 3 | |
| RhoGEF | 3 | |
| Tubulin_C | 2 | |
| GST_N | 2 | |
| STAT_int | 2 | |
| Myosin_head | 2 | |
| GTP_EFTU | 2 | |
| Ldh_1_C | 2 | |
| Cpn10 | 1 | |
| CPSF73-100_C | 1 | |
| SSB | 1 | |
| PGK | 1 | |
| WH1 | 1 | |
| Ribosomal_L7Ae | 1 | |
| RhoGAP | 1 | |
| Histone | 1 | |
| Aminotran_1_2 | 1 | |
| G6PD_C | 1 | |
| G6PD_N | 1 | |
| RRM_1 | 1 | |
| Ras | 1 | |
| Ribosomal_S13_N | 1 | |
| PH | 1 | |
| Enolase_N | 1 | |
| Enolase_C | 1 | |
| FERM_C | 1 | |
| EF_hand_5 | 1 | |
| DEAD | 1 |
PFAM Domains
| Domain | Peptides | |
|---|---|---|
| None | 22 | |
| Pkinase | 16 | |
| SH2 | 14 | |
| SH3_1 | 12 | |
| PH | 8 | |
| Pkinase_Tyr | 7 | |
| SH3_2 | 5 | |
| RhoGAP | 5 | |
| Y_phosphatase | 3 | |
| Proteasome | 3 | |
| RA | 3 | |
| Tubulin | 2 | |
| Tubulin_C | 2 | |
| PDZ | 2 | |
| GST_C | 2 | |
| GST_N | 2 | |
| HATPase_c | 2 | |
| RRM_1 | 2 | |
| Rtt106 | 2 | |
| RhoGEF | 2 | |
| C2 | 2 | |
| STAT_bind | 2 | |
| STAT_int | 2 | |
| Myosin_head | 2 | |
| Myosin_N | 2 | |
| Proteasome_A_N | 2 | |
| ArfGap | 2 | |
| Ldh_1_C | 2 | |
| SAM_2 | 2 | |
| FERM_M | 2 | |
| FERM_N | 2 | |
| LIM | 1 | |
| His_Phos_1 | 1 | |
| Glycolytic | 1 | |
| DnaJ | 1 | |
| DnaJ_C | 1 | |
| Cpn10 | 1 | |
| Autophagy_N | 1 | |
| Autophagy_act_C | 1 | |
| Autophagy_Cterm | 1 | |
| zf-UBP | 1 | |
| DUSP | 1 | |
| Cofilin_ADF | 1 | |
| F5_F8_type_C | 1 | |
| VWA_2 | 1 | |
| MMS1_N | 1 | |
| CPSF73-100_C | 1 | |
| Beta-Casp | 1 | |
| Lactamase_B | 1 | |
| Peptidase_M24 | 1 | |
| TFR_dimer | 1 | |
| HATPase_c_3 | 1 | |
| IRS | 1 | |
| GTPase_binding | 1 | |
| SSB | 1 | |
| PGK | 1 | |
| UEV | 1 | |
| Vps23_core | 1 | |
| WH1 | 1 | |
| VASP_tetra | 1 | |
| Clathrin_H_link | 1 | |
| Clathrin-link | 1 | |
| Methyltransf_31 | 1 | |
| Ribosomal_L7Ae | 1 | |
| tRNA_anti | 1 | |
| SAM_1 | 1 | |
| Histone | 1 | |
| Aminotran_1_2 | 1 | |
| GTP_EFTU | 1 | |
| GTP_EFTU_D3 | 1 | |
| GTP_EFTU_D2 | 1 | |
| G6PD_C | 1 | |
| G6PD_N | 1 | |
| BRO1 | 1 | |
| ALIX_LYPXL_bnd | 1 | |
| PID | 1 | |
| NUC153 | 1 | |
| Hydrolase | 1 | |
| Cation_ATPase_N | 1 | |
| OMPdecase | 1 | |
| Pribosyltran | 1 | |
| Hrs_helical | 1 | |
| BPS | 1 | |
| Ras | 1 | |
| Bcr-Abl_Oligo | 1 | |
| SSrecog | 1 | |
| HMG_box | 1 | |
| Ribosomal_S13_N | 1 | |
| Ribosomal_S15 | 1 | |
| CH | 1 | |
| Death | 1 | |
| Ank_4 | 1 | |
| LSR | 1 | |
| Enolase_C | 1 | |
| Enolase_N | 1 | |
| Anticodon_1 | 1 | |
| F_actin_bind | 1 | |
| FERM_C | 1 | |
| Exo_endo_phos | 1 | |
| EF_hand_5 | 1 | |
| Transglut_N | 1 | |
| Transglut_C | 1 | |
| Talin_middle | 1 | |
| VBS | 1 | |
| DEAD | 1 |