An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells

GO Map

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Molecular Functions

GO Term Proteins
temp None - 31
temp GO:0005515 protein binding 25
temp GO:0044822 poly(A) RNA binding 6
temp GO:0003677 DNA binding 4
temp GO:0003700 sequence-specific DNA binding transcription factor activity 4
temp GO:0003682 chromatin binding 3
temp GO:0098641 cadherin binding involved in cell-cell adhesion 3
temp GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 2
temp GO:0003678 DNA helicase activity 2
temp GO:0005496 steroid binding 2
temp GO:0005524 ATP binding 2
temp GO:0008094 DNA-dependent ATPase activity 2
temp GO:0008190 eukaryotic initiation factor 4E binding 2
temp GO:0019901 protein kinase binding 2
temp GO:0020037 heme binding 2
temp GO:0030371 translation repressor activity 2
temp GO:0042802 identical protein binding 2
temp GO:0000049 tRNA binding 1
temp GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 1
temp GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 1
temp GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity 1
temp GO:0001076 RNA polymerase II transcription factor binding transcription factor activity 1
temp GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 1
temp GO:0001085 RNA polymerase II transcription factor binding 1
temp GO:0001102 RNA polymerase II activating transcription factor binding 1
temp GO:0001105 RNA polymerase II transcription coactivator activity 1
temp GO:0001158 enhancer sequence-specific DNA binding 1
temp GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 1
temp GO:0002039 p53 binding 1
temp GO:0003676 nucleic acid binding 1
temp GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity 1
temp GO:0003707 steroid hormone receptor activity 1
temp GO:0003713 transcription coactivator activity 1
temp GO:0003723 RNA binding 1
temp GO:0003727 single-stranded RNA binding 1
temp GO:0003729 mRNA binding 1
temp GO:0003743 translation initiation factor activity 1
temp GO:0004312 fatty acid synthase activity 1
temp GO:0004402 histone acetyltransferase activity 1
temp GO:0004674 protein serine/threonine kinase activity 1
temp GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 1
temp GO:0005080 protein kinase C binding 1
temp GO:0005096 GTPase activator activity 1
temp GO:0008013 beta-catenin binding 1
temp GO:0008017 microtubule binding 1
temp GO:0008022 protein C-terminus binding 1
temp GO:0008140 cAMP response element binding protein binding 1
temp GO:0008157 protein phosphatase 1 binding 1
temp GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity 1
temp GO:0017137 Rab GTPase binding 1
temp GO:0030296 protein tyrosine kinase activator activity 1
temp GO:0030971 receptor tyrosine kinase binding 1
temp GO:0031369 translation initiation factor binding 1
temp GO:0031625 ubiquitin protein ligase binding 1
temp GO:0032403 protein complex binding 1
temp GO:0033613 activating transcription factor binding 1
temp GO:0035035 histone acetyltransferase binding 1
temp GO:0035064 methylated histone residue binding 1
temp GO:0035497 cAMP response element binding 1
temp GO:0042169 SH2 domain binding 1
temp GO:0042393 histone binding 1
temp GO:0042826 histone deacetylase binding 1
temp GO:0043130 ubiquitin binding 1
temp GO:0043565 sequence-specific DNA binding 1
temp GO:0046332 SMAD binding 1
temp GO:0046982 protein heterodimerization activity 1
temp GO:0047485 protein N-terminus binding 1
temp GO:0051018 protein kinase A binding 1
temp GO:0070063 RNA polymerase binding 1

Cellular Components

GO Term Proteins
None - 31
GO:0005634 nucleus 13
GO:0005654 nucleoplasm 13
GO:0005829 cytosol 13
GO:0005737 cytoplasm 12
GO:0005730 nucleolus 10
GO:0016020 membrane 6
GO:0070062 extracellular vesicular exosome 5
GO:0005886 plasma membrane 4
GO:0005783 endoplasmic reticulum 3
GO:0005913 cell-cell adherens junction 3
GO:0005794 Golgi apparatus 2
GO:0008023 transcription elongation factor complex 2
GO:0012505 endomembrane system 2
GO:0043231 intracellular membrane-bounded organelle 2
GO:0055038 recycling endosome membrane 2
GO:0000778 condensed nuclear chromosome kinetochore 1
GO:0000784 nuclear chromosome, telomeric region 1
GO:0000790 nuclear chromatin 1
GO:0000932 cytoplasmic mRNA processing body 1
GO:0000940 condensed chromosome outer kinetochore 1
GO:0001650 fibrillar center 1
GO:0005635 nuclear envelope 1
GO:0005667 transcription factor complex 1
GO:0005732 small nucleolar ribonucleoprotein complex 1
GO:0005739 mitochondrion 1
GO:0005741 mitochondrial outer membrane 1
GO:0005776 autophagic vacuole 1
GO:0005777 peroxisome 1
GO:0005811 lipid particle 1
GO:0005813 centrosome 1
GO:0005852 eukaryotic translation initiation factor 3 complex 1
GO:0005876 spindle microtubule 1
GO:0005971 ribonucleoside-diphosphate reductase complex 1
GO:0009986 cell surface 1
GO:0010008 endosome membrane 1
GO:0015630 microtubule cytoskeleton 1
GO:0016021 integral to membrane 1
GO:0016234 inclusion body 1
GO:0016235 aggresome 1
GO:0016605 PML body 1
GO:0016607 nuclear speck 1
GO:0020018 ciliary pocket membrane 1
GO:0030529 ribonucleoprotein complex 1
GO:0030660 Golgi-associated vesicle membrane 1
GO:0031095 platelet dense tubular network membrane 1
GO:0031901 early endosome membrane 1
GO:0031965 nuclear membrane 1
GO:0032040 small-subunit processome 1
GO:0034457 Mpp10 complex 1
GO:0035327 transcriptionally active chromatin 1
GO:0035371 microtubule plus end 1
GO:0035861 site of double-strand break 1
GO:0043234 protein complex 1
GO:0044753 amphisome 1
GO:0044754 autolysosome 1
GO:0071013 catalytic step 2 spliceosome 1
GO:0071339 MLL1 complex 1

Biological Processes

GO Term Proteins
None - 32
GO:0006366 transcription from RNA polymerase II promoter 4
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 4
GO:0006412 translation 3
GO:0010467 gene expression 3
GO:0044267 cellular protein metabolic process 3
GO:0000082 G1/S transition of mitotic cell cycle 2
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 2
GO:0000278 mitotic cell cycle 2
GO:0002224 toll-like receptor signaling pathway 2
GO:0002755 MyD88-dependent toll-like receptor signaling pathway 2
GO:0002756 MyD88-independent toll-like receptor signaling pathway 2
GO:0006355 regulation of transcription, DNA-dependent 2
GO:0006396 RNA processing 2
GO:0006413 translational initiation 2
GO:0006915 apoptotic process 2
GO:0008063 Toll signaling pathway 2
GO:0008380 RNA splicing 2
GO:0031929 TOR signaling cascade 2
GO:0032456 endocytic recycling 2
GO:0034130 toll-like receptor 1 signaling pathway 2
GO:0034134 toll-like receptor 2 signaling pathway 2
GO:0034138 toll-like receptor 3 signaling pathway 2
GO:0034142 toll-like receptor 4 signaling pathway 2
GO:0034146 toll-like receptor 5 signaling pathway 2
GO:0034162 toll-like receptor 9 signaling pathway 2
GO:0034166 toll-like receptor 10 signaling pathway 2
GO:0035556 intracellular signal transduction 2
GO:0035666 TRIF-dependent toll-like receptor signaling pathway 2
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway 2
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway 2
GO:0043065 positive regulation of apoptotic process 2
GO:0044281 small molecule metabolic process 2
GO:0045087 innate immune response 2
GO:0045892 negative regulation of transcription, DNA-dependent 2
GO:0045947 negative regulation of translational initiation 2
GO:0048011 nerve growth factor receptor signaling pathway 2
GO:0051260 protein homooligomerization 2
GO:0051403 stress-activated MAPK cascade 2
GO:0000002 mitochondrial genome maintenance 1
GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle 1
GO:0000087 M phase of mitotic cell cycle 1
GO:0000090 mitotic anaphase 1
GO:0000165 MAPK cascade 1
GO:0000236 mitotic prometaphase 1
GO:0000375 RNA splicing, via transesterification reactions 1
GO:0000398 mRNA splicing, via spliceosome 1
GO:0000422 mitochondrion degradation 1
GO:0001649 osteoblast differentiation 1
GO:0006112 energy reserve metabolic process 1
GO:0006260 DNA replication 1
GO:0006281 DNA repair 1
GO:0006283 transcription-coupled nucleotide-excision repair 1
GO:0006284 base-excision repair 1
GO:0006289 nucleotide-excision repair 1
GO:0006325 chromatin organization 1
GO:0006334 nucleosome assembly 1
GO:0006351 transcription, DNA-dependent 1
GO:0006357 regulation of transcription from RNA polymerase II promoter 1
GO:0006364 rRNA processing 1
GO:0006400 tRNA modification 1
GO:0006468 protein phosphorylation 1
GO:0006511 ubiquitin-dependent protein catabolic process 1
GO:0006631 fatty acid metabolic process 1
GO:0006766 vitamin metabolic process 1
GO:0006767 water-soluble vitamin metabolic process 1
GO:0006886 intracellular protein transport 1
GO:0006888 ER to Golgi vesicle-mediated transport 1
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 1
GO:0006897 endocytosis 1
GO:0006914 autophagy 1
GO:0006917 induction of apoptosis 1
GO:0006950 response to stress 1
GO:0006970 response to osmotic stress 1
GO:0006974 response to DNA damage stimulus 1
GO:0006979 response to oxidative stress 1
GO:0006987 activation of signaling protein activity involved in unfolded protein response 1
GO:0007010 cytoskeleton organization 1
GO:0007020 microtubule nucleation 1
GO:0007059 chromosome segregation 1
GO:0007062 sister chromatid cohesion 1
GO:0007067 mitosis 1
GO:0007165 signal transduction 1
GO:0007243 intracellular protein kinase cascade 1
GO:0007264 small GTPase mediated signal transduction 1
GO:0007417 central nervous system development 1
GO:0007420 brain development 1
GO:0007507 heart development 1
GO:0007517 muscle organ development 1
GO:0007596 blood coagulation 1
GO:0007613 memory 1
GO:0008015 blood circulation 1
GO:0008104 protein localization 1
GO:0008286 insulin receptor signaling pathway 1
GO:0008334 histone mRNA metabolic process 1
GO:0008360 regulation of cell shape 1
GO:0008543 fibroblast growth factor receptor signaling pathway 1
GO:0009263 deoxyribonucleotide biosynthetic process 1
GO:0009411 response to UV 1
GO:0010613 positive regulation of cardiac muscle hypertrophy 1
GO:0010738 regulation of protein kinase A signaling cascade 1
GO:0010821 regulation of mitochondrion organization 1
GO:0010886 positive regulation of cholesterol storage 1
GO:0010923 negative regulation of phosphatase activity 1
GO:0015939 pantothenate metabolic process 1
GO:0015949 nucleobase-containing small molecule interconversion 1
GO:0016044 cellular membrane organization 1
GO:0016197 endosomal transport 1
GO:0016236 macroautophagy 1
GO:0016239 positive regulation of macroautophagy 1
GO:0016477 cell migration 1
GO:0016573 histone acetylation 1
GO:0019432 triglyceride biosynthetic process 1
GO:0030178 negative regulation of Wnt receptor signaling pathway 1
GO:0030490 maturation of SSU-rRNA 1
GO:0030968 endoplasmic reticulum unfolded protein response 1
GO:0031110 regulation of microtubule polymerization or depolymerization 1
GO:0031116 positive regulation of microtubule polymerization 1
GO:0031122 cytoplasmic microtubule organization 1
GO:0031175 neuron projection development 1
GO:0031325 positive regulation of cellular metabolic process 1
GO:0031573 intra-S DNA damage checkpoint 1
GO:0032508 DNA duplex unwinding 1
GO:0032784 regulation of DNA-dependent transcription, elongation 1
GO:0032786 positive regulation of DNA-dependent transcription, elongation 1
GO:0034080 CENP-A containing nucleosome assembly at centromere 1
GO:0034383 low-density lipoprotein particle clearance 1
GO:0035176 social behavior 1
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1
GO:0036498 IRE1-mediated unfolded protein response 1
GO:0042632 cholesterol homeostasis 1
GO:0042692 muscle cell differentiation 1
GO:0043044 ATP-dependent chromatin remodeling 1
GO:0043066 negative regulation of apoptotic process 1
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade 1
GO:0043401 steroid hormone mediated signaling pathway 1
GO:0043484 regulation of RNA splicing 1
GO:0043547 positive regulation of GTPase activity 1
GO:0043620 regulation of DNA-dependent transcription in response to stress 1
GO:0044255 cellular lipid metabolic process 1
GO:0045727 positive regulation of translation 1
GO:0045815 positive regulation of gene expression, epigenetic 1
GO:0045893 positive regulation of transcription, DNA-dependent 1
GO:0045931 positive regulation of mitotic cell cycle 1
GO:0045945 positive regulation of transcription from RNA polymerase III promoter 1
GO:0046578 regulation of Ras protein signal transduction 1
GO:0048167 regulation of synaptic plasticity 1
GO:0048205 COPI coating of Golgi vesicle 1
GO:0048311 mitochondrion distribution 1
GO:0048565 digestive tract development 1
GO:0048813 dendrite morphogenesis 1
GO:0050790 regulation of catalytic activity 1
GO:0050804 regulation of synaptic transmission 1
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity 1
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity 1
GO:0051149 positive regulation of muscle cell differentiation 1
GO:0051301 cell division 1
GO:0055005 ventricular cardiac myofibril development 1
GO:0055086 nucleobase-containing small molecule metabolic process 1
GO:0060070 canonical Wnt receptor signaling pathway 1
GO:0060271 cilium morphogenesis 1
GO:0061024 membrane organization 1
GO:0061098 positive regulation of protein tyrosine kinase activity 1
GO:0061337 cardiac conduction 1
GO:0061512 protein localization to cilium 1
GO:0061635 regulation of protein complex stability 1
GO:0070375 ERK5 cascade 1
GO:0070884 regulation of calcineurin-NFAT signaling cascade 1
GO:0071277 cellular response to calcium ion 1
GO:0075522 IRES-dependent viral translational initiation 1
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway 1
GO:0097190 apoptotic signaling pathway 1
GO:0098779 activation of mitophagy in response to mitochondrial depolarization 1
GO:1901741 positive regulation of myoblast fusion 1
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1
GO:1902416 positive regulation of mRNA binding 1
GO:1903146 regulation of mitochondrion degradation 1
GO:1903608 protein localization to cytoplasmic stress granule 1
GO:1990090 cellular response to nerve growth factor stimulus 1
GO:2000144 positive regulation of DNA-dependent transcription, initiation 1
GO:2001022 positive regulation of response to DNA damage stimulus 1
GO:2001137 positive regulation of endocytic recycling 1
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 1